KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCR
All Species:
31.21
Human Site:
S349
Identified Species:
49.05
UniProt:
P04035
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04035
NP_000850.1
888
97476
S349
T
E
T
E
S
T
L
S
L
K
N
P
I
T
S
Chimpanzee
Pan troglodytes
XP_001148324
888
97313
S349
T
E
T
E
S
T
L
S
L
K
N
P
I
T
S
Rhesus Macaque
Macaca mulatta
XP_001104607
888
97210
S349
A
E
T
E
S
T
L
S
L
K
N
P
I
T
S
Dog
Lupus familis
XP_536323
888
97475
S349
A
E
T
E
S
T
L
S
L
K
N
P
I
T
S
Cat
Felis silvestris
Mouse
Mus musculus
Q01237
887
97003
S349
A
E
T
E
S
T
L
S
L
K
N
P
I
T
S
Rat
Rattus norvegicus
P51639
887
96670
S349
A
E
T
E
S
T
L
S
L
K
N
P
I
T
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989816
875
95421
P347
L
K
N
P
I
T
S
P
V
T
V
Q
K
K
V
Frog
Xenopus laevis
P20715
883
96702
S351
T
E
T
E
S
T
F
S
M
K
N
P
I
I
S
Zebra Danio
Brachydanio rerio
NP_001119931
893
97691
S350
V
E
M
E
S
T
L
S
L
K
V
P
T
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P14773
920
98299
S397
L
P
D
Q
L
R
Q
S
G
P
V
A
I
A
A
Honey Bee
Apis mellifera
XP_623118
908
99432
Q352
E
D
I
A
K
Q
L
Q
F
K
V
E
D
D
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P16393
932
100947
R348
L
A
T
Y
P
E
K
R
V
S
I
M
E
G
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O24594
579
60912
S105
A
F
V
Q
S
I
V
S
S
G
D
D
D
E
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P14891
592
63579
Q118
F
F
G
I
D
F
V
Q
S
F
I
S
R
A
S
Baker's Yeast
Sacchar. cerevisiae
P12683
1054
115607
A494
L
L
R
N
V
S
V
A
I
R
D
R
F
V
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.7
95.7
N.A.
93.3
92.7
N.A.
N.A.
85.1
80.9
77.8
N.A.
47.2
51.2
N.A.
56.3
Protein Similarity:
100
99.7
99.3
97.3
N.A.
96
95.8
N.A.
N.A.
91.6
89.5
86.7
N.A.
64.6
69.2
N.A.
70.6
P-Site Identity:
100
100
93.3
93.3
N.A.
93.3
93.3
N.A.
N.A.
6.6
80
66.6
N.A.
13.3
13.3
N.A.
6.6
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
93.3
N.A.
N.A.
20
86.6
66.6
N.A.
26.6
26.6
N.A.
13.3
Percent
Protein Identity:
N.A.
33.5
N.A.
34.5
35.1
N.A.
Protein Similarity:
N.A.
46.8
N.A.
47.5
51
N.A.
P-Site Identity:
N.A.
13.3
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
13.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
34
7
0
7
0
0
0
7
0
0
0
7
0
14
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
0
7
0
0
0
0
0
14
7
14
7
7
% D
% Glu:
7
54
0
54
0
7
0
0
0
0
0
7
7
7
0
% E
% Phe:
7
14
0
0
0
7
7
0
7
7
0
0
7
0
0
% F
% Gly:
0
0
7
0
0
0
0
0
7
7
0
0
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
7
7
7
7
0
0
7
0
14
0
54
7
0
% I
% Lys:
0
7
0
0
7
0
7
0
0
60
0
0
7
7
0
% K
% Leu:
27
7
0
0
7
0
54
0
47
0
0
0
0
0
0
% L
% Met:
0
0
7
0
0
0
0
0
7
0
0
7
0
0
0
% M
% Asn:
0
0
7
7
0
0
0
0
0
0
47
0
0
0
0
% N
% Pro:
0
7
0
7
7
0
0
7
0
7
0
54
0
7
0
% P
% Gln:
0
0
0
14
0
7
7
14
0
0
0
7
0
0
0
% Q
% Arg:
0
0
7
0
0
7
0
7
0
7
0
7
7
0
0
% R
% Ser:
0
0
0
0
60
7
7
67
14
7
0
7
0
0
67
% S
% Thr:
20
0
54
0
0
60
0
0
0
7
0
0
7
40
7
% T
% Val:
7
0
7
0
7
0
20
0
14
0
27
0
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _